Protein name:
Glutamate decarboxylase 2 ;
Alternative:
Glutamate decarboxylase 65 kDa isoform ;65 kDa glutamic acid decarboxylase (GAD-65) ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Catalyzes the production of GABA.
Subcellular Location:
Cytoplasm
cytosol
Cytoplasmic vesicle
Cell junction
synapse
presynaptic cell membrane
Lipid-anchor
Golgi apparatus membrane
Peripheral membrane protein
Cytoplasmic side
Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
Protein Attributes:
50:
MASPGSGFWS | FGSEDGSGDS | ENPGTARAWC | QVAQKFTGGI | GNKLCALLYG |
100:
DAEKPAESGG | SQPPRAAARK | AACACDQKPC | SCSKVDVNYA | FLHATDLLPA |
150:
CDGERPTLAF | LQDVMNILLQ | YVVKSFDRST | KVIDFHYPNE | LLQEYNWELA |
200:
DQPQNLEEIL | MHCQTTLKYA | IKTGHPRYFN | QLSTGLDMVG | LAADWLTSTA |
250:
NTNMFTYEIA | PVFVLLEYVT | LKKMREIIGW | PGGSGDGIFS | PGGAISNMYA |
300:
MMIARFKMFP | EVKEKGMAAL | PRLIAFTSEH | SHFSLKKGAA | ALGIGTDSVI |
350:
LIKCDERGKM | IPSDLERRIL | EAKQKGFVPF | LVSATAGTTV | YGAFDPLLAV |
400:
ADICKKYKIW | MHVDAAWGGG | LLMSRKHKWK | LSGVERANSV | TWNPHKMMGV |
450:
PLQCSALLVR | EEGLMQNCNQ | MHASYLFQQD | KHYDLSYDTG | DKALQCGRHV |
500:
DVFKLWLMWR | AKGTTGFEAH | VDKCLELAEY | LYNIIKNREG | YEMVFDGKPQ |
550:
HTNVCFWYIP | PSLRTLEDNE | ERMSRLSKVA | PVIKARMMEY | GTTMVSYQPL |
585:
GDKVNFFRMV | ISNPAATHQD | IDFLIEEIER | LGQDL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Dog
Human
Pig
Rat
ELISA Kit for Human Glutamate decarboxylase 2
ELISA Kit for Human Glutamate decarboxylase 2
ELISA Kit for Human Glutamate decarboxylase 2
ELISA Kit for Human Glutamate decarboxylase 2
ELISA Kit for Human Glutamate decarboxylase 2
CLIA Kit for Human Glutamate decarboxylase 2
CLIA Kit for Human Glutamate decarboxylase 2
CLIA Kit for Human Glutamate decarboxylase 2
CLIA Kit for Human Glutamate decarboxylase 2
CLIA Kit for Human Glutamate decarboxylase 2
Polyclonal Antibody for Human Glutamate decarboxylase 2
Polyclonal Antibody for Human Glutamate decarboxylase 2
Polyclonal Antibody for Human Glutamate decarboxylase 2
Polyclonal Antibody for Human Glutamate decarboxylase 2
Polyclonal Antibody for Human Glutamate decarboxylase 2
Monoclonal Antibody for Human Glutamate decarboxylase 2
Monoclonal Antibody for Human Glutamate decarboxylase 2
Monoclonal Antibody for Human Glutamate decarboxylase 2
Monoclonal Antibody for Human Glutamate decarboxylase 2
Monoclonal Antibody for Human Glutamate decarboxylase 2
Protein for Human Glutamate decarboxylase 2
Protein for Human Glutamate decarboxylase 2
Protein for Human Glutamate decarboxylase 2
Protein for Human Glutamate decarboxylase 2
Protein for Human Glutamate decarboxylase 2
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
"Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10."
Karlsen A.E.
,
Hagopian W.A.
,
Grubin C.E.
,
Dube S.
,
Disteche C.M.
,
Adler D.A.
,
Barmeier H.
,
Mathewes S.
,
Grant F.J.
,
Foster D.
,
Lernmark A.
Proc. Natl. Acad. Sci. U.S.A.88:8337-8341(1991)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Pancreatic islet .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-12; ASN-124; ARG-286 AND GLN-375
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 6-585
tissue :
Pancreas .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 245-585
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-3; SER-6; SER-10 AND SER-13;BIOPHYSICOCHEMICAL PROPERTIES
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;PALMITOYLATION AT CYS-30 AND CYS-45
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 222-235 IN COMPLEX WITH MHC
10.
"GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop."
Fenalti G.
,
Law R.H.P.
,
Buckle A.M.
,
Langendorf C.
,
Tuck K.
,
Rosado C.J.
,
Faux N.G.
,
Mahmood K.
,
Hampe C.S.
,
Banga J.P.
,
Wilce M.
,
Schmidberger J.
,
Rossjohn J.
,
El-Kabbani O.
,
Pike R.N.
,
Smith A.I.
,
Mackay I.R.
,
Rowley M.J.
,
Whisstock J.C.
more...
Nat. Struct. Mol. Biol.14:280-286(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 88-584 IN COMPLEX WITH SUBSTRATE;SUBUNIT;COFACTOR